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KMID : 0355620090350030137
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Journal of Korean Association of Oral and Maxillofacial Surgeons
2009 Volume.35 No. 3 p.137 ~ p.445
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BONE REGENERATION WITH MMP SENSITIVE HYALURONIC ACID-BASED HYDROGEL, rhBMP-2 AND NANOPARTICLES IN RAT CALVARIAL CRITICAL SIZE DEFECT(CSD) MODEL
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Nam Jeong-Hun
Park Jong-Chul
Yoo Sang-Bae
Chung Yong-Il
Tae Gi-Yoong
Kim Jung-Ju
Park Yong-Doo
Jahng Jeong-Won
Lee Jong-Ho
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Abstract
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As an efficient controlled release system for rhBMP-2, a functional nanoparticle-hydrogel complex, incorporated with matrix metalloproteinase(MMP) sensitive peptide cross-linker, was developed and used as a bone transplant. In vivo bone formation was evaluated by soft x-ray, histology, alkaline phosphatase(ALP) activity and mineral contents analysis, based on the rat calvarial critical size defect(8mm in diameter) model.
Significantly, effective bone regeneration was achieved with the rhBMP-2 loaded MMP sensitive hyaluronic acid(HA) based hydrogel-Nanoparticles(NP) complex, as compared to only MMP HA, the MMP HA-NP without rhBMP-2, or even with the rhBMP-2. These improvements included the formation pattern of bone and functional marrow, the degree of calcium quantification, and the ALP activity.
These results indicate that the MMP sensitive HA with nano-particle complex can be a promising candidate for a new bone defect replacement matrix, and an enhanced rhBMP-2 scaffold.
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KEYWORD
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matrix metalloproteinase(MMP), hyaluronic acid, controlled release, rhBMP-2, nanoparticle, MMP sensitive hydrogel
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